Download PDF by Beverly A. (Ed.) Teicher,Beverly A. Teicher: Cancer Drug Resistance (Cancer Drug Discovery and

By Beverly A. (Ed.) Teicher,Beverly A. Teicher

top specialists summarize and synthesize the newest discoveries in regards to the alterations that happen in tumor cells as they improve resistance to anticancer medicines, and recommend new techniques to fighting and overcoming it. The authors evaluation physiological resistance dependent upon tumor structure, mobile resistance in accordance with drug delivery, epigenetic adjustments that neutralize or skip drug cytotoxicity, and genetic adjustments that regulate drug aim molecules through lowering or taking away drug binding and efficacy. Highlights comprise new insights into resistance to antiangiogenic cures, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the advance of more suitable remedies. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. (Ed.) Teicher,Beverly A. Teicher


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